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The Bone Broth Diet: A Complete Guide
by Kellyann Petrucci
on May 18 2026
I have been asked one question more than any other in the last decade of my practice: does the Bone Broth Diet actually work? It is a fair question. The wellness industry is full of programs that promise transformation and deliver disappointment. So when patients ask me to walk them through what the Bone Broth Diet actually is, how it works, what to realistically expect, and whether there is real research behind it, I am happy to take the time. This guide is that conversation. I am going to walk you through the program in plain language, share the published clinical research, and tell you honestly what to expect and who this is not for.
What the Bone Broth Diet Actually Is
The Bone Broth Diet is a 21-day program I developed and detailed in my New York Times bestselling book of the same name. The structure is straightforward. You follow a 5:2 pattern. Five days a week you eat portion-controlled meals built around high-quality protein, non-starchy vegetables, healthy fats, and bone broth. Two non-consecutive days a week you keep things simple with bone broth and protein-based mini-meals. You repeat this pattern for three weeks.
The premise is rooted in how the body actually responds to food and fasting at a metabolic level. When you give your body adequate protein, lower the inflammatory load by removing grains and sugars, and create predictable windows of metabolic rest, real change happens. The bone broth is not a gimmick. It is doing specific work in this program. The amino acids in bone broth, particularly glycine, proline, and hydroxyproline, support the gut lining, help moderate hunger between meals, and provide the kind of slow-burning nourishment the body wants during a fasting window.
Let me be clear about what this is not. The Bone Broth Diet is not a bone broth fast. You are not living on broth alone for 21 days. It is not a juice cleanse. It is not keto, although it shares some structural similarities with low-carb approaches. It is not water-only fasting, which I do not recommend for most women. The Bone Broth Diet is a structured 21-day program with real food, designed to be followed for a defined period of time. If you want to follow the full protocol with day-by-day meal plans and shopping lists, the official Bone Broth Diet program is where I have laid all of that out.
This guide is the educational version. By the end of it, you will know what the program is, what the research shows, what to eat, what to expect, whether it is safe for you, and how it compares to other approaches. I will be honest about the limitations and equally honest about the results.
The Science: What a 2025 Clinical Trial Showed
Most popular diets have lots of indirect evidence and no published clinical trial on the actual program. The Bone Broth Diet is in a small minority of consumer wellness programs that have been tested in a peer-reviewed clinical setting and had the results published in a medical journal. I think that matters, and I want to walk you through exactly what was done and what was found.
In 2025, an 8-week clinical trial of the Bone Broth Diet was published in the journal Clinical Nutrition Open Science, which is published by Elsevier on behalf of the European Society for Clinical Nutrition and Metabolism1. I want to be transparent about how the study was structured because this honesty matters. The trial was funded by Veyl Ventures, which is the parent company of the Dr. Kellyann brand. The trial itself was conducted by KGK Science, an independent Canadian clinical research organization, and the authors of the published paper are KGK Science scientists, not employees of my brand. The study was prospectively registered with ClinicalTrials.gov under the identifier NCT05740670, followed CONSORT reporting guidelines for clinical trials, and received ethics approval from the Advarra Institutional Review Board. That methodological rigor is what allows a study to be published in a peer-reviewed journal in the first place.
What the trial measured
The study enrolled 100 adults between the ages of 35 and 65 with a body mass index between 30 and 39.9, meaning the participants were in the obesity range but were otherwise generally healthy. Participants completed two 3-week phases of the Bone Broth Diet with one-week maintenance phases between, for a total of 8 weeks. The researchers measured changes in body weight, BMI, body composition, waist circumference, blood markers including glucose and lipids, hunger and craving ratings, and quality of life across multiple dimensions.
What the trial found
Participants lost an average of approximately 15 pounds, or about 6.8 kilograms, over the 8-week study period1. Waist circumference decreased by 6.3 centimeters, which is about two and a half inches. Sagittal abdominal diameter, which is a measure of belly depth and a strong predictor of cardiometabolic risk, decreased by 2.6 centimeters across the full study period.
Importantly, the weight loss came from fat mass while muscle mass was preserved1. This is the difference between a program that helps you lose body fat and a program that just makes the scale move at the expense of the muscle you need for long-term metabolic health.
The metabolic markers improved as well. Fasting blood glucose decreased significantly. Triglycerides decreased by 0.43 mmol/L across the full study period, a statistically significant finding (P < 0.001)1. Participants reported significant decreases in hunger and cravings during the program, and yet they also reported no reduction in satisfaction after eating. That last finding is meaningful. People did not feel deprived, even on the mini-fasting days.
Quality of life improved across physical functioning, energy, pain, emotional well-being, and general health1. And the program was found to be safe and well-tolerated. No serious adverse events were reported during the study.
Honest limitations
The authors are transparent about the study limitations, and so am I. This was an open-label, single-arm trial, which means there was no placebo control group. Participants knew they were on the Bone Broth Diet. The trial population was specifically adults in the obesity range. The duration was 8 weeks, not a year. The authors themselves note in their published conclusions that "future randomized controlled trials of longer duration are recommended to verify and understand the sustainability of results"1. I share that caveat in good faith. The trial is meaningful clinical evidence, and it is one step in a research conversation that should continue.
How the Diet Works: The 5:2 Framework
Most people who hear "intermittent fasting" think of the time-restricted eating windows that have become popular, like fasting from 8 p.m. to noon the next day. The Bone Broth Diet uses a different fasting structure called 5:2. Five days a week, you eat normally according to the food list. Two non-consecutive days a week, you do what I call mini-fasting, which means most of your daily intake comes from bone broth with optional protein-based snacks if you need them.
The reason I chose 5:2 over daily time-restricted eating is that it is more flexible, easier to sustain, and the metabolic effects are well documented. Most women I work with find it easier to fully focus on two structured fasting days per week than to maintain a daily eating window every single day. And the research backs this up.
A 2025 systematic review and network meta-analysis published in the BMJ analyzed 99 randomized clinical trials with 6,582 adults to compare different intermittent fasting strategies3. The review found that intermittent fasting approaches produced weight loss and cardiometabolic benefits comparable to continuous calorie restriction, with some strategies showing additional advantages for triglycerides, blood pressure, and cholesterol. The Bone Broth Diet falls into a category the researchers call whole-day fasting, which they found particularly effective for body weight outcomes in trials of 24 weeks or more.
So what is actually happening on the mini-fasting days? Your body shifts from primarily burning glucose to burning stored fat for fuel. Insulin levels drop. Inflammation markers tend to decrease. The body gets a window of metabolic rest from the constant work of digesting and processing food. And on the feeding days, the higher protein intake supports muscle preservation while you are losing fat.
The bone broth is doing specific work here that plain water fasting would not do. The amino acids in bone broth, especially glycine, provide the body with raw materials for collagen synthesis, gut lining repair, and detoxification pathways during the fasting window. A 2024 systematic review in GeroScience examined the effects of glycine administration across 11 physiological systems in human adults and found documented benefits for sleep, inflammation, and cellular protection6. Bone broth is one of the richest dietary sources of glycine you can get.
Research from the University of Pittsburgh published in 2024 also documents how fasting interacts with protein metabolism at the level of bone remodeling, with methionine acting as a regulator of how the body adapts to fasting periods4. The mechanisms are real, and they are why this 5:2 plus bone broth structure works differently than just cutting calories.
If you want to go deeper on the fasting-plus-bone-broth combination, I have written more about it in intermittent fasting with bone broth and I have also discussed it with Dr. Oz in this conversation about intermittent fasting for weight loss.
What You Eat: The Food List
I get asked all the time for the food list, so let me give it to you in plain terms. On feeding days, you are building plates around protein, non-starchy vegetables, and healthy fats, with bone broth as a daily anchor. On mini-fasting days, bone broth does most of the work.
Foods you will be enjoying
Protein. Grass-fed beef, pasture-raised poultry, wild-caught fish, eggs, and bison are the foundation. Aim for a palm-sized portion at each main meal.
Non-starchy vegetables. Leafy greens, cruciferous vegetables, asparagus, peppers, cucumbers, zucchini, mushrooms, tomatoes. Generous portions. Aim for at least half your plate.
Healthy fats. Avocado, olive oil, coconut oil, ghee, and small amounts of nuts and seeds. Fat is not the enemy on this program. It supports satiety and hormone production.
Bone broth. At least one cup daily, ideally more. This is the daily anchor. You can sip it warm in a mug, use it as a base for soups, or drink a cup as part of your breakfast routine.
Low-glycemic fruits in moderation. Berries, apples, citrus. Save these for once or twice a day, not all-day grazing.
Foods you will be skipping for 21 days
Grains. This includes wheat, rice, oats, corn, and gluten-free grains. The 21-day window is not forever. You may add some grains back during the maintenance phase.
Legumes. Beans, lentils, peanuts. Same logic as grains.
Dairy. With the exception of ghee, which is clarified butter and tolerated by most people. Dairy comes back as an option during reintroduction.
Refined sugar and artificial sweeteners. The fewer hidden sugars in your day, the more responsive your metabolism will be.
Processed seed oils. Soybean oil, corn oil, canola oil. These are pro-inflammatory and undermine the work you are doing.
Alcohol. For the 21 days, alcohol is off the menu. It interferes with fat metabolism and disrupts sleep, both of which matter for your results.
On the mini-fasting days, your day looks simple. Three to six cups of bone broth, optionally with a small protein-based snack like a hard-boiled egg, a few slices of deli meat with no added sugar, or a couple of tablespoons of nuts if you genuinely need it. The simplicity is part of the point. You are giving your digestive system a break and letting the bone broth do its work. If you want a starting point for sourcing high-quality bone broth, the Dr. Kellyann bone broth collection has options for every preference. My Classic Chicken Bone Broth is the most popular and the easiest to weave into daily life.
You can absolutely make your own bone broth, and I have shared my Instant Pot recipe for anyone who wants to do that. Most of the women in my practice end up doing both — making their own when they have time and stocking high-quality store-bought options for everything else.
What to Expect: Results, Timeline, and What Is Realistic
I want to give you the honest picture, not the marketing version. Here is what the published clinical research showed, and here is what I see in my practice.
The clinical trial found that participants lost an average of about 15 pounds over 8 weeks, with a 6.3 cm reduction in waist circumference and 2.6 cm reduction in sagittal abdominal diameter1. In my practice, the most successful people on the 21-day Bone Broth Diet have lost up to 15 pounds and 4 inches from their waist in just 21 days. Results vary based on your starting point, how closely you follow the program, your age, your hormonal stage, and a dozen other factors. People with more to lose typically lose more in absolute terms. People who are already lean tend to see results in measurements and energy rather than dramatic scale changes.
A general week-by-week framework
Week one is adaptation. The first two to three days are when most people experience the most adjustment. You may notice some hunger, occasional headache, or fatigue as your body shifts from running on quick-burning carbs to burning fat. This is normal and short-lived. By the end of week one, most people report better energy, less bloating, and improved sleep.
Week two is momentum. Your body has adapted. Waist circumference is usually the first place people notice visible change. The scale starts moving more consistently. Mini-fasting days feel manageable instead of difficult. Cravings have usually decreased significantly by this point.
Week three is consolidation. This is where the real metabolic and aesthetic changes show up. Many of my patients tell me their skin looks better. Their clothes fit differently. Their energy is more even throughout the day. The scale may show a slowdown in week three, but body composition is often still shifting in your favor.
Why muscle preservation matters
Most weight-loss approaches cause you to lose muscle along with fat. That is a problem. Muscle is what keeps your metabolism running, supports your bones, and protects you against the gradual decline most people experience as they age. The clinical trial of the Bone Broth Diet specifically documented fat loss with muscle preservation1. This matters for long-term success. The independent research on protein intake during weight loss confirms this pattern. A 2024 systematic review and meta-analysis in Clinical Nutrition ESPEN found that adults with overweight or obesity who increased their protein intake during weight loss were significantly better at preserving muscle mass than those who did not5. The minimum protein intake associated with muscle preservation was 1.3 grams per kilogram of body weight per day, which is exactly the territory the Bone Broth Diet falls into on feeding days.
Energy and skin
Many customers report energy improvements within the first week of the program. The bloating that comes from grains, dairy, and processed foods often resolves quickly once those foods are removed. Skin improvements typically take 14 to 21 days to become visible, since skin turnover is a slower process. Research suggests that the amino acid profile of bone broth, particularly glycine, may support skin and connective tissue. Many customers report glowing skin by the end of the 21 days, though I would not promise it.
If you want to see what real customer journeys on the Bone Broth Diet look like, Brock’s story and Ben’s 22-pound transformation are honest accounts of what changed for them.
Is the Bone Broth Diet Safe?
The published clinical trial found that the Bone Broth Diet was safe and well-tolerated in healthy adults with obesity, with no serious adverse events reported during the 8-week study1. That is the most rigorous evidence we have on safety, and it is consistent with what I have seen in clinical practice for over a decade.
Common transient side effects
I want to be honest about what some people experience during the first few days, because being prepared for it makes it easier to push through.
Mild hunger during the first two to three days. This is normal as your body adjusts to the 5:2 structure. It typically resolves by the end of week one.
Occasional headache during the adaptation period. Often related to changes in sodium and electrolytes. Bone broth itself helps with this since it provides natural sodium and minerals.
Some fatigue in the first few days as your body shifts to burning fat for fuel. This usually transitions into improved, more stable energy by mid-week one.
Mild digestive shifts as the gut adjusts to a higher-protein, higher-vegetable, lower-carbohydrate intake.
None of these are serious, and they all typically resolve within the first week. But if you experience anything that feels significant or persistent, talk to your healthcare provider.
Who should not do the Bone Broth Diet
I am a naturopathic physician, and I am also a realist. This program is not for everyone, and there are specific people I would ask to talk to their healthcare provider before considering it.
Women who are pregnant or breastfeeding. This is not the right time for a structured weight-loss program. Your body needs steady, abundant nourishment.
People with active eating disorders or a history of disordered eating. Any structured eating program can be a trigger. The right step here is working with a mental health professional first.
People on medications that require precise food timing, especially diabetes medications and blood thinners. The mini-fasting days change food timing, and medication dosing may need adjustment by your prescribing physician.
People with chronic kidney disease. The higher protein intake on feeding days needs medical guidance in this population.
Anyone with a serious medical condition. Talk to your doctor first. The Bone Broth Diet is a tool, not a substitute for medical care.
On the bone broth quality question
Some critics raise concerns about heavy metals or contaminants in bone broth, particularly broth made from unknown sources. The most authoritative recent review of bone broth from Mayo Clinic published in 2025 in Digestive Diseases and Sciences looked at the nutritional profile and clinical applications of bone broth in depth and found that the amino acid and mineral content support a meaningful role in supporting gut barrier integrity2. The practical reality is that the quality of your bone broth matters. Commercial bone broth that is properly sourced and tested is safer than home-made broth from unknown bones. I formulated my own bone broth line for exactly this reason. Quality of source, simmer time, and testing all matter.
And to be clear, this is a 21-day structured program, not an extreme fast. It is not a juice cleanse. It is not water-only fasting. It is not unsupervised long-term restriction. You are eating real food on five days a week, and the two mini-fasting days are anchored by bone broth, which is itself nourishing food. This is one of the safer structured weight-loss approaches available.
Bone Broth Diet vs. Other Approaches
I get this question all the time. Should I do the Bone Broth Diet or keto? Should I do this or my regular intermittent fasting? Let me walk through how the Bone Broth Diet compares to the most common alternatives my patients ask about.
Bone Broth Diet vs. keto
Both approaches are lower in carbohydrates than a standard American diet. The Bone Broth Diet is not strictly ketogenic. It includes more vegetables and low-glycemic fruits than a true ketogenic diet typically does, and the 5:2 fasting structure is what drives much of the metabolic effect. Keto has no fasting structure built in. The Bone Broth Diet uses bone broth as a daily anchor for amino acid intake and gut support, which keto does not specifically prioritize. For most women in midlife, I find the Bone Broth Diet structure is more sustainable than long-term strict ketosis.
Bone Broth Diet vs. traditional intermittent fasting
Same 5:2 backbone, very different experience. Traditional intermittent fasting on a fasting day usually means water, coffee, and sometimes a small amount of food. The Bone Broth Diet replaces that empty-calorie window with bone broth, which provides amino acids, minerals, and electrolytes during the fasting window. People often find the Bone Broth Diet much more sustainable than water-only fasting precisely because the bone broth softens the experience of the fasting days.
Bone Broth Diet vs. the 5-Day Cleanse and Reset. My 5-Day Cleanse and Reset is a shorter, lower-commitment program focused on gut health and inflammation. It is designed as a fast win. The Bone Broth Diet is a deeper 21-day transformation that includes weight loss as a primary outcome. Many women use the Cleanse and Reset as an entry point and then move to the Bone Broth Diet if they want a fuller transformation.
Bone Broth Diet vs. the 10-Day Belly Slimdown. The 10-Day Belly Slimdown is gut and bloat-focused, with a shorter 10-day commitment. The Bone Broth Diet is longer and deeper, designed for more significant body composition change. Both share the bone broth foundation.
Bone Broth Diet vs. a bone broth cleanse
There is some confusion in search results around "bone broth cleanse" terminology. A bone broth cleanse usually implies a fully liquid program with bone broth as the only intake for a stretch of days. The Bone Broth Diet is not that. It is a structured program with real food on feeding days. If you have seen "bone broth cleanse" content elsewhere and thought it sounded extreme, that is because much of it is. The Bone Broth Diet is the sustainable, evidence-based alternative.
Common Questions Before You Start
Before the full FAQ section below, let me address a handful of the questions I hear most often when someone is making the decision to start.
Can I do this if I am vegetarian? The Bone Broth Diet is built around animal protein and bone broth, so a strictly vegan version is not possible. But many vegetarians do an adapted version successfully. I have written specifically about how to adapt the Bone Broth Diet if you are vegetarian, and the short version is yes, with thoughtful protein substitutions and a vegetable-based broth as an alternative.
Can I exercise while doing this? Yes, and gentle to moderate movement is encouraged. Walking, yoga, light strength training, and stretching all work well. I would not recommend pushing into very intense training during week one when your body is still adapting. Listen to your body. If you feel strong, train. If you feel tired, rest.
Can I drink coffee? Yes, in moderation. One to two cups per day is fine, ideally with breakfast or before noon to support your natural cortisol rhythm. Avoid loading it up with cream and sugar. Black coffee, or coffee with a small splash of unsweetened nut milk, is the move.
How is this different from the book? The Bone Broth Diet was first published as a book and has been refined and updated as I have worked with thousands of patients and customers. The current program reflects everything I have learned. The book is still a wonderful resource and gives you the philosophy behind the program. The program itself, with the most current meal plans, recipes, and bone broth pairing, lives on my site.
How to Start
If you have read this far, you are clearly considering doing this. Here is how I would start if I were sitting across from you in my office.
Pick a start date. Choose a Monday or Tuesday so the first three days of adaptation happen during the work week. Avoid starting right before a major social event or a vacation.
Clear your kitchen of obvious obstacles. Foods you know are going to call your name during the first few days, get them out of sight or out of the house. You will thank yourself.
Stock up on the basics. Protein for the week, plenty of vegetables, healthy fats, a good supply of bone broth, and a few low-glycemic fruits. Plan to grocery shop twice during the 21 days.
Pick up your bone broth. You can make it yourself or buy quality, well-sourced broth. Either works. Plan for at least 5 to 7 cups per week.
Track how you feel, not just the scale. Keep a notebook or a simple app where you note energy, sleep, digestion, mood, waist measurement, and how your clothes fit. The scale is only one signal.
Commit to 21 days. Not 21 days minus the weekend at the cabin. Not 21 days unless something comes up. Twenty-one days, fully. That is where the transformation lives.
If you want the full program with the day-by-day meal plan, the complete recipe library, the shopping lists, and everything mapped out so you do not have to think about it, the Bone Broth Diet program has all of that built in. The 21-Day Bone Broth Diet Bundle includes everything you need to begin. And if you want a smaller starting point, my 7-day bone broth lifestyle meal plan is a lower-commitment way to test the waters first.
Choosing Your Bone Broth: Formats, Flavors, and What I Recommend
I get asked all the time which of my bone broths to start with, and the honest answer is that it depends on how you want to use them. Some women want a savory mug they can sip while making dinner. Others want a quick concentrate they can stir into hot water on a busy morning. Some are doing the full 21-day Bone Broth Diet and want a variety pack so they do not get bored. Let me walk you through how the product line is structured and what I would recommend based on how you want to weave bone broth into your life.
Start by choosing your format
My bone broth comes in three main formats, and each fits a different lifestyle. There is no wrong choice. Pick the one you will actually use.
Concentrates and frozen broths. These are the closest thing to a homemade simmered broth. You warm them up, sip from a mug, or use them as a base for soups and pan sauces. My Classic Chicken Bone Broth and Classic Beef Bone Broth are the foundation of the line. If you are doing the 21-day program, these will be the workhorses in your fridge.
Ready-to-drink liquid broths. Shelf-stable, no preparation, perfect for on-the-go life. Pour into a mug, microwave, sip. The Classic Beef Low-Sodium Liquid Broth, French Onion Liquid Broth, and Thai Lemongrass Liquid Broth are designed for the busy person who wants the benefits of bone broth without thinking about it. These are also the easiest option to keep at your desk or in your bag.
Powders and capsules. For travel, for skipping breakfast, for adding into smoothies and shakes. My Bone Broth Protein in Vanilla is the cleanest collagen-rich protein source you can stir into a glass of nut milk in ten seconds. The Bone Broth Capsules are the simplest possible way to keep the daily habit going when you are traveling or have a packed week. Different format, same amino acid profile.
Then choose your flavors
I created the flavor range because I wanted bone broth to fit into real life, not just sit in the back of the fridge. Variety is what keeps people drinking bone broth daily for years. Here is how the flavor profiles break down.
The savory foundation. Classic Chicken and Classic Beef are clean, traditional, and the most versatile. These are what I would start a new customer on. Drink them as is, use them as a soup base, cook your vegetables in them.
The elevated flavors. Roasted Rosemary Chicken is herbal and warming. French Onion tastes like a bistro soup in a mug. Greek Lemon Chicken is bright and citrusy, my answer for when you want bone broth but you are tired of the deeper savory profiles. Homestyle Mushroom is earthy and umami-rich, particularly satisfying on the mini-fasting days when you want depth without heaviness.
The bolder, more adventurous flavors. Thai Lemongrass is bright and aromatic with a hint of heat. Sriracha Chicken has real kick and is a favorite among people who want something more lively in the afternoon. Ramen Beef delivers that deep, rich ramen-shop flavor at home. These are the ones to reach for when your taste buds are bored.
The plant-based option. My Vegan Garden Vegetable Broth is for vegetarian and vegan customers, and also for anyone who wants a lighter, plant-forward broth option on certain days. It does not contain the collagen amino acids that bone broth does, but it is a nourishing, clean broth that fits the same routine.
The protein powders. My bone broth protein powders are designed for shakes, smoothies, and dessert-style applications. Vanilla is the most versatile and pairs with almost anything. Chocolate is the customer favorite for chocolate shakes and bone broth hot chocolate. Salted Caramel is the one for when you want dessert without the dessert. All three deliver the same collagen-rich amino acid profile as my savory broths, just in a sweet format.
What I would recommend based on where you are
If you are new to bone broth. Start with Classic Chicken or Classic Beef. Drink one cup daily for two weeks. See how you feel. Most people notice better digestion, more even energy, and improved sleep within that window.
If you are doing the full 21-day Bone Broth Diet. The 21-Day Bone Broth Diet Bundle includes everything you need to begin, and the 21-Day Assorted Bundle gives you five flavors so you do not get bored. Variety is what carries you through three weeks. Boredom is the silent killer of any structured program.
If you travel often or skip breakfast. The Bone Broth Protein powders or the Bone Broth Capsules will keep your daily habit alive when life gets in the way. The powders also double as a fast breakfast when blended into a smoothie.
If you want the full range. The bone broth bundles collection is where I have grouped my most popular pairings. Building your own bundle of two classic flavors and two elevated flavors is what I recommend to my customers who want their daily bone broth practice to feel like something to look forward to, not a chore.
Frequently Asked Questions
What is the Bone Broth Diet in simple terms?
The Bone Broth Diet is a 21-day program that pairs five-day-a-week portion-controlled meals built around protein, vegetables, and healthy fats with two non-consecutive mini-fasting days each week. Bone broth is the daily anchor across the entire program. The diet was tested in a peer-reviewed clinical trial published in 20251.
How quickly will I see results on the Bone Broth Diet?
Most people notice changes within the first week, particularly in bloating, energy, and how their clothes fit. Visible body composition changes typically become clear by the end of week two. The published clinical trial documented an average weight loss of about 15 pounds and 6.3 cm waist circumference reduction over 8 weeks1. Many customers see similar results within the 21-day program. Results vary based on starting point and adherence.
Is the Bone Broth Diet safe for older adults?
The clinical trial included adults up to age 65 and found the program was safe and well-tolerated1. For adults over 65, the program can still be appropriate but I always recommend a conversation with your healthcare provider first, especially if you take medications or have any chronic health conditions. Adequate protein intake, which the Bone Broth Diet supports, is particularly important for muscle preservation in older adults5.
Can I do the Bone Broth Diet while taking medication?
It depends entirely on the medication. The mini-fasting days change your food timing, which can affect how some medications are absorbed or how their dosing should be adjusted. Diabetes medications, blood thinners, blood pressure medications, and thyroid medications are the most important ones to discuss with your prescribing physician before starting. Never adjust your medication on your own. Talk to your doctor first.
How much bone broth do I need to drink on the Bone Broth Diet?
On feeding days, aim for at least one to two cups of bone broth daily. On mini-fasting days, plan for three to six cups distributed throughout the day. The bone broth is doing real work in this program, providing amino acids and minerals that support the fasting window6.
Will I lose muscle on the Bone Broth Diet?
The clinical trial specifically documented fat loss with muscle preservation across the 8-week study period1. The high-protein feeding days are designed to protect muscle mass during weight loss, and the independent research on protein intake during weight loss supports this approach. The 2024 meta-analysis in Clinical Nutrition ESPEN found that protein intakes of at least 1.3 grams per kilogram of body weight per day significantly preserved muscle mass during weight loss5.
What happens after the 21 days on the Bone Broth Diet?
Reintroduction is the key phase that follows the 21 days. You gradually add back foods you eliminated, one category at a time, paying close attention to how each food makes you feel. Many people discover sensitivities they never knew they had. I have written specifically about reintroducing foods after the 21-day Bone Broth Diet to walk through this phase. Many people also continue with bone broth as a daily habit indefinitely.
Can I do the Bone Broth Diet during perimenopause or menopause?
Yes, and many women find the Bone Broth Diet especially helpful during perimenopause and menopause because the high-protein structure supports muscle preservation at exactly the life stage when muscle loss is accelerated. The 5:2 structure can be modified if needed to honor your energy levels and hormonal rhythms. If you are deep in perimenopausal symptoms, going more gradually or starting with the 5-Day Cleanse and Reset first may serve you better.
Is the Bone Broth Diet the same as a bone broth fast?
No. A bone broth fast usually means consuming only bone broth for an extended period of days, which is a much more restrictive approach. The Bone Broth Diet is a structured 21-day program with real food on five days each week and bone broth as the anchor across all 21 days. The Bone Broth Diet is sustainable and supported by clinical research1. An extended bone broth fast is not something I would recommend for most people.
Can I drink alcohol on the Bone Broth Diet?
I ask people to skip alcohol for the full 21 days of the Bone Broth Diet. Alcohol interferes with fat metabolism, disrupts sleep, increases inflammation, and undermines almost every benefit you are working toward. It is only 21 days. Most people find that by the end of the program they have a different relationship with alcohol anyway, and many choose to keep it minimal or skip it entirely going forward.
Where to Start Today
If you take one thing from this guide, let it be this. The Bone Broth Diet is not a fad and it is not magic. It is a structured 21-day program with real food, a fasting framework that respects how the body actually works, and a daily bone broth practice that supports the gut, the metabolism, and the body’s nutritional needs during a transformation window. It has been tested in a peer-reviewed clinical trial, and the published results are meaningful. The trial documented an average of about 15 pounds of weight loss with fat reduction, muscle preservation, improved metabolic markers, and a positive safety profile, all over 8 weeks.
Twenty-one days is the right length for a transformation to take root. Pick your start date, plan your food, get your bone broth supply ready, and commit. If you want the full program with the meal plan, recipes, and step-by-step guidance, the Bone Broth Diet program is right here. If you want a shorter starting point, the 5-Day Cleanse and Reset is a wonderful on-ramp. Either way, you have the science behind you and a real protocol to follow. Start there.
References
1. Doma KM, Moulin M, Al-Wahsh H, Guthrie N, Crowley DC, Lewis ED. An open-label clinical trial to investigate the safety and efficacy of a bone broth diet on weight loss in adults with obesity. Clin Nutr Open Sci. 2025;61:231-240. (Funded by Veyl Ventures LLC; conducted by KGK Science Inc., an independent clinical research organization; ClinicalTrials.gov NCT05740670.) Available at: https://www.sciencedirect.com/science/article/pii/S2667268525000488
2. Matar A, Abdelnaem N, Camilleri M. Bone Broth Benefits: How Its Nutrients Fortify Gut Barrier in Health and Disease. Dig Dis Sci. 2025;70(6):1951-1961. Available at: https://pubmed.ncbi.nlm.nih.gov/40180691/
3. Semnani-Azad Z, Khan TA, Chiavaroli L, et al. Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials. BMJ. 2025;389:e082007. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175170/
4. Amorim T, Kumar NGV, David NL, et al. Methionine as a regulator of bone remodeling with fasting. JCI Insight. 2024;9(11):e177997. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11383369/
5. Kokura Y, Ueshima J, Saino Y, Maeda K. Enhanced protein intake on maintaining muscle mass, strength, and physical function in adults with overweight/obesity: A systematic review and meta-analysis. Clin Nutr ESPEN. 2024;63:417-426. Available at: https://www.sciencedirect.com/science/article/abs/pii/S2405457724001761
6. Soh J, Raventhiran S, Lee JH, Lim ZX, Goh J, Kennedy BK, Maier AB. The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review. GeroScience. 2024;46(1):219-239. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828290/
These statements have not been evaluated by the Food and Drug Administration. Dr. Kellyann products and programs are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Many customers report results consistent with those described in this article, and individual experiences differ based on starting point, adherence, age, hormonal status, and other factors. Consult your healthcare provider before starting any new dietary program, especially if you are pregnant, nursing, taking medication, or have a medical condition.
Guides
Gut Health: The Complete Guide to What It Is, Why It Matters, and How to Support It
by Kellyann Petrucci
on May 18 2026
After two decades of practice, here is what I can tell you with certainty. The gut is not just where digestion happens. It is the foundation underneath most of the other things people come to me for. Energy. Skin. Mood. Hormones. Weight. Immunity. Sleep. When the gut is well, most of the rest of the body has the support it needs to function. When the gut is struggling, almost nothing else works the way it should. This guide is about what gut health actually is, why it matters so much more than most people realize, what science tells us about supporting it, and the practical daily habits that make the biggest difference. By the end you will have a clear, evidence-based understanding and a real action plan, not buzzwords.
What Gut Health Actually Means
"Gut health" gets used as a buzzword, so let me define what we are actually talking about. Gut health refers to the integrated function of the entire digestive system, from the mouth through the small and large intestines. It includes the integrity of the intestinal barrier, the composition and diversity of the microbiome, the efficiency of digestion and nutrient absorption, the gut’s immune function, and the gut-brain communication that influences mood and cognition.
When all of these functions are working well, digestion is easy and predictable, you absorb the nutrients from your food, your immune system is calm and responsive, your mood is steady, your skin is clear, your energy is even, and the dozens of other downstream functions the gut influences are running smoothly. When any of these gut functions break down, the downstream effects show up in places that often do not feel like they are related to the gut at all.
The Three Pillars of Gut Health
When I talk about gut health with patients, I find it helpful to break it down into three pillars. These are not separate systems. They influence and depend on each other. But understanding them separately makes the path forward clearer.
Pillar one: the intestinal barrier
The intestinal barrier is a single-cell-thick lining that runs through your entire digestive tract. It is the most important and most underappreciated structure in your body. This thin layer of cells, held together by tight junctions, decides what passes from your digestive tract into your bloodstream. Nutrients pass through. Bacteria, toxins, undigested food particles, and inflammatory triggers do not. When the barrier is working well, you are protected. When the barrier becomes compromised, what the research community calls intestinal hyperpermeability, the cascade of problems begins. A 2024 review in Clinical and Experimental Medicine published by researchers at Jagiellonian University Medical College in Poland walks through the specific mechanisms by which the intestinal barrier becomes damaged and the dietary and lifestyle strategies that may support its repair2.
Pillar two: the microbiome
Your gut contains trillions of bacteria, fungi, archaea, and viruses, collectively called the microbiome. The microbiome is genuinely a separate ecosystem, with more genetic material than your own human cells. It manufactures vitamins, breaks down fiber into short-chain fatty acids that nourish the gut lining, regulates the immune system, communicates with the brain through the vagus nerve and the chemicals it produces, and shapes how you absorb and respond to food. A diverse, well-fed, balanced microbiome is one of the strongest predictors of overall health that we can currently measure. I have written more on the microbiome specifically in why you need to protect your microbiome and making your gut bugs happy.
Pillar three: the gut-brain axis
The gut and the brain are in constant communication through the vagus nerve, the immune system, and the chemicals that the microbiome produces. About 90 percent of your serotonin, the neurotransmitter most associated with mood regulation, is actually produced in the gut. The gut-brain axis is why people with chronic gut symptoms often also experience anxiety, low mood, brain fog, and sleep disruption. And it is why when you fix the gut, those other symptoms often improve too. I have written more on the gut-brain connection for anyone who wants to explore that further.
What Damages Gut Health
The same modern conveniences that make life easier are surprisingly hard on the gut. None of this is meant to make anyone feel guilty. It is just the truth about what is happening when the gut struggles, and being honest about it is the first step in fixing it.
A 2024 review published in Clinical and Experimental Medicine documents the most significant factors that compromise the intestinal barrier and disrupt the microbiome2. They include the following.
Ultra-processed foods and the additives and emulsifiers they contain. The food itself is the most consistent driver of gut dysfunction in the modern diet.
Chronic stress. The gut is exquisitely sensitive to stress hormones. Long-term stress disrupts microbiome composition and damages the intestinal barrier.
Alcohol, particularly in regular or heavy use. Alcohol directly damages the intestinal lining and disrupts the microbiome.
Antibiotics. Necessary when truly indicated, but each course of antibiotics reduces microbiome diversity, sometimes significantly. Recovery takes weeks to months.
NSAIDs and certain other medications. Frequent use of ibuprofen and similar drugs damages the intestinal lining over time.
Poor sleep. The microbiome has its own circadian rhythm. Disrupted sleep disrupts gut health.
A diet low in fiber and plant diversity. The microbiome eats fiber. Without enough variety, microbial diversity declines.
Excessive sugar intake. Feeds the wrong bacteria and disrupts the balance.
Environmental toxins, pesticides, and certain food preservatives.
If any of this is sounding familiar, you are not alone. Most adults in modern life have a few of these factors operating at any given time. The point of identifying them is not blame. It is to understand that gut health is largely modifiable, often dramatically so. For more on the most common gut-damaging foods, I have a piece on common foods that cause digestive distress that walks through the practical food side.
What Leaky Gut Actually Is
"Leaky gut" is one of those terms that has moved from clinical literature into popular wellness, and along the way it has picked up some confusion. Let me give you the straight clinical answer.
Leaky gut, more accurately called intestinal hyperpermeability or increased intestinal permeability, refers to a measurable condition in which the tight junctions between the cells lining your gut become loose. When this happens, substances that should be kept inside the digestive tract, including bacterial fragments, undigested proteins, and inflammatory compounds, can pass into the bloodstream where they trigger immune and inflammatory responses. This is a documented phenomenon that is measured in clinical research using validated probe molecules and other diagnostic methods2.
The research community accepts that intestinal hyperpermeability exists and is associated with a range of conditions, including inflammatory bowel disease, irritable bowel syndrome, celiac disease, certain autoimmune conditions, and possibly some metabolic and neurological conditions. What is still being clarified is the precise role intestinal permeability plays as a cause versus a consequence in different conditions, and the most effective interventions for restoring barrier function.
Common symptoms people describe when their gut barrier is compromised include bloating, gas, food sensitivities that seem to come out of nowhere, fatigue, brain fog, skin issues, joint stiffness, and unexplained inflammation. None of these are diagnostic by themselves. But when several of them appear together, particularly after a known gut-disrupting event like a course of antibiotics or a period of high stress, the gut barrier is worth supporting. I have a deeper piece on understanding leaky gut syndrome for anyone wanting to go further.
The Foundational Habits That Support Gut Health
Before anything else, before any supplements or specialty products, the foundational habits are what move the needle most. These are not glamorous. They are also the most powerful. If you do nothing else from this article, do these.
Eat real food
The single biggest thing you can do for your gut is to shift the bulk of your diet toward minimally processed real food. Whole vegetables, quality protein, fruits, nuts, seeds, beans if you tolerate them, fermented foods, and bone broth. The fewer ultra-processed foods in your week, the better your gut will function. You do not have to be perfect. You just have to be moving consistently in the right direction.
Diversify your plants
The microbiome eats fiber, and different microbes prefer different kinds of fiber. The single best dietary marker for microbiome diversity is the number of different plant foods you eat in a week. The current research suggests that 30 different plant species per week is a strong target. Plants count: vegetables, fruits, nuts, seeds, herbs, spices, beans, whole grains if you tolerate them. A handful of different colors of bell peppers, a variety of leafy greens, a few different berries, herbs in your cooking. Diversity is the key.
Add fermented foods
Fermented foods like sauerkraut, kimchi, yogurt, kefir, and miso deliver live beneficial bacteria along with the metabolites those bacteria produce. Daily small amounts of fermented food are one of the most consistently helpful additions in my practice. I have a piece on adding fermented foods for gut health that goes deeper into the practical side.
Include bone broth daily
I will say more about this in the next section, but a daily cup of bone broth is one of the simplest gut-supportive habits. The amino acids in bone broth, especially glycine and glutamine, are the building blocks the body uses to maintain and repair the intestinal lining1.
Sleep
Sleep is gut health. Aim for 7 to 9 hours per night with a consistent schedule. Poor sleep disrupts the microbiome’s own circadian rhythm and damages the intestinal barrier. If your sleep is bad, that is the first thing to address, not a probiotic.
Manage stress
The gut-brain axis means stress shows up in the gut almost immediately. Walking, breath work, meditation, time outside, anything that reliably brings your nervous system down. This is not optional. Chronic stress will undo every other gut-supportive habit if you do not address it.
Move your body daily
Regular moderate movement improves microbiome diversity, supports gut motility, and reduces stress. A daily walk is one of the most underrated gut interventions there is.
I have a longer piece on 8 tips to reset your gut and how to improve gut health that walk through the same foundations in more practical detail.
Why Bone Broth Is Central to Gut Healing
There is a reason bone broth has been associated with healing and recovery in nearly every traditional culture in the world. The science is now catching up with what traditional wisdom has known for a long time. Bone broth provides the specific nutritional building blocks the gut needs to maintain and repair itself.
A 2025 review published in Digestive Diseases and Sciences by researchers at the Mayo Clinic specifically examined how bone broth nutrients support the gut barrier in health and disease1. The mechanism is clear. The amino acids in bone broth, particularly glycine, proline, hydroxyproline, and glutamine, are directly involved in maintaining and repairing the intestinal lining.
Glycine has documented anti-inflammatory properties and supports the mucosal layer that protects the gut wall. A 2024 systematic review in GeroScience examined the effects of glycine administration on multiple physiological systems and confirmed its supportive role in inflammation regulation, cellular protection, and sleep3. Glutamine is the primary fuel source for the cells lining the small intestine. When the gut lining is depleted or damaged, glutamine demand increases. Bone broth provides both of these amino acids in their natural food matrix.
In practical terms, adding a daily cup of bone broth to your routine is one of the most efficient gut-supportive habits you can adopt. It pairs naturally with fermented foods and a fiber-rich, plant-diverse diet to form the foundation of daily gut nourishment. Many of my patients report noticeable improvements in digestion, bloating, and food tolerance within two to three weeks of daily bone broth.
I have written more specifically on bone broth and gut health for anyone wanting to go deeper.
Prebiotics, Probiotics, and Postbiotics
You will hear these three terms a lot in any conversation about gut health. They are not interchangeable. Here is what each actually does.
Probiotics
Probiotics are live beneficial bacteria that may add to or temporarily support the microbial communities in your gut. They come from fermented foods like yogurt, kefir, sauerkraut, kimchi, and miso, and from supplements. The honest truth about probiotic supplements is that the research is mixed. Some strains have documented benefits for specific conditions. Many products on the market have unclear or unproven strain-level effects. If you are going to take a probiotic supplement, choose one with researched strains and trust the food forms of probiotics first. Fermented foods are usually the better path.
Prebiotics
Prebiotics are the fibers and compounds that the beneficial bacteria in your gut eat. The microbiome is only as healthy as what you feed it. Prebiotics come from a wide variety of plant foods: onions, garlic, leeks, asparagus, artichokes, oats, apples, bananas, flax seeds. A diverse plant-rich diet is naturally rich in prebiotics. Most people would benefit more from increasing their prebiotic intake from food than from taking a probiotic supplement.
Postbiotics
Postbiotics are the compounds that the gut microbes produce when they ferment fiber. Short-chain fatty acids like butyrate are the most important examples. Butyrate is the primary fuel for the cells lining the colon and has powerful anti-inflammatory effects. You do not eat postbiotics directly. You support them by feeding the microbes that produce them, which means eating enough fiber and a diverse range of plants.
I have a piece on prebiotics and probiotics for a healthy gut microbiome that walks through the practical application in more detail.
Gut Health, Skin, Energy, and Mood
I want to spend a moment on why the downstream effects of gut health matter so much, because this is where the foundation of the whole article comes together.
Gut and skin
What shows up on the skin is often what is happening in the gut. The gut-skin axis is a real phenomenon. When the gut is inflamed, the skin is often inflamed. When the gut barrier is compromised, skin conditions like acne, rosacea, and eczema can flare. When the gut heals, the skin often clears. I have a dedicated piece on gut health and skin for anyone whose primary concern is the skin side of this equation.
Gut and energy
Your energy depends on how well you absorb nutrients from your food, on the systemic inflammatory load your body is carrying, and on the gut-brain communication that regulates mitochondrial function. All three of these are downstream of gut health. When my patients describe persistent low energy that is not explained by sleep or thyroid issues, gut health is the next place I look.
Gut and mood
About 90 percent of the body’s serotonin is produced in the gut. The microbiome produces neurotransmitter precursors. The vagus nerve carries gut signals directly to the brain. When the gut is struggling, mood often struggles. When the gut is supported, mood often follows. This is not a substitute for proper mental health care when that is needed. But the gut piece of mood regulation is real and underappreciated.
Gut and hormones
The gut microbiome contains specific bacteria that metabolize estrogen, sometimes called the estrobolome. Disruption of the estrobolome contributes to the hormonal imbalances many women experience in perimenopause and beyond. Supporting gut health is part of supporting hormonal balance.
Programs and Tools That Reset the Gut
For some people, daily habits are enough. For others, especially those coming off a long period of poor habits, illness, antibiotics, or chronic stress, a more structured reset is helpful. Here are the approaches I use in my own practice.
The 5-Day Cleanse and Reset
A short, focused 5-day reset designed to give the digestive system a break, reduce inflammation, and reset eating patterns. The 5-Day Cleanse and Reset is the entry point I most often recommend for someone who wants to feel a quick improvement and reset their baseline. This is not a juice cleanse or an extreme restriction. It is a structured short-term program with real food.
The 10-Day Belly Slimdown
A 10-day gut-and-bloat focused program. The 10-Day Belly Slimdown is for the person whose main symptom is bloating and digestive discomfort, and who wants a slightly longer commitment than the 5-day reset.
The 21-Day Bone Broth Diet
A 21-day program that combines intermittent fasting with daily bone broth and a real-food eating plan. The Bone Broth Diet is the deeper transformation. The 2025 clinical trial of the program documented significant improvements in waist circumference, glucose, triglycerides, and quality of life4, and the 5:2 intermittent fasting structure gives the digestive system regular periods of metabolic rest. A 2025 BMJ network meta-analysis confirms that fasting strategies like the 5:2 framework produce significant cardiometabolic benefits in trials of 24 weeks or more5.
Daily bone broth as the anchor
Whether or not you do a structured program, daily bone broth is the simplest and most consistent gut-supportive habit you can adopt. My bone broth collection is what I recommend, with Classic Chicken as the easiest starting point. For travel or busy days, the Bone Broth Capsules keep the habit going. And for a morning shake or smoothie, the Bone Broth Protein powder delivers the same amino acid profile in a convenient form.
Frequently Asked Questions
How long does it take to heal the gut?
It depends on the starting point. For most people with mild gut symptoms, noticeable improvements happen within 2 to 4 weeks of consistent gut-supportive habits. More significant gut damage from long-term antibiotic use, chronic stress, or established dysbiosis can take 3 to 6 months or longer to fully address. The intestinal lining itself replaces its cells about every 5 to 7 days, which is why dietary changes can produce noticeable shifts quickly.
What are the signs of an unhealthy gut?
Common signs include frequent bloating, gas, indigestion, constipation or diarrhea, unexplained fatigue, brain fog, skin issues, recurrent infections, food sensitivities that come on suddenly, irregular sleep, low mood, and joint stiffness. Any one of these alone is not diagnostic, but when several appear together, particularly after a known gut-disrupting event like antibiotics or a period of high stress, it is worth giving the gut focused attention.
Can leaky gut be reversed?
Yes, in most cases. The intestinal lining replaces itself rapidly, so providing the right nutritional building blocks and removing the triggers that are damaging the barrier allows healing to happen. A 2024 review documents the dietary and lifestyle strategies most supported by current research2. The amino acids in bone broth, particularly glycine and glutamine, are central to this restorative process1.
Is bone broth good for gut health?
Yes. A 2025 Mayo Clinic review specifically documented how bone broth nutrients support the gut barrier1. The amino acids glycine, proline, hydroxyproline, and glutamine, all abundant in bone broth, are directly involved in maintaining and repairing the intestinal lining.
Do I need a probiotic supplement?
Not necessarily. Most people benefit more from regular consumption of fermented foods like sauerkraut, kimchi, kefir, and yogurt than from probiotic supplements. Probiotic supplements have a place after antibiotic use, during travel, or for specific conditions where research supports particular strains. But they are not a replacement for the foundational habits of fiber-rich eating, fermented foods, and bone broth.
How many different plants should I eat each week?
The current research suggests that 30 different plant species per week is a strong target for microbiome diversity. This sounds like a lot but it adds up quickly when you count herbs, spices, different colors of vegetables, varieties of fruit, nuts, seeds, beans, and grains if you tolerate them. Keeping a list for a week can be eye-opening.
Can stress really damage my gut?
Yes, and quickly. Chronic stress disrupts microbiome composition, compromises intestinal barrier function, slows gut motility, and changes how the body produces and uses neurotransmitters in the gut2. Stress management is not optional in gut health. It is foundational.
What is the gut-brain connection?
The gut and brain are in constant two-way communication through the vagus nerve, the immune system, and the chemicals the microbiome produces. About 90 percent of the body’s serotonin is produced in the gut. This is why gut health influences mood, anxiety, and cognitive function, and why those things in turn influence gut function.
Does intermittent fasting help gut health?
Yes, in most people. Giving the digestive system regular extended periods without food appears to support microbiome diversity, allow the migrating motor complex to clear residual food and bacteria from the small intestine, and reduce inflammatory load. A 2025 BMJ network meta-analysis documents the broader cardiometabolic benefits of intermittent fasting strategies5. The 5:2 framework I use in the Bone Broth Diet is particularly gentle on the gut.
Can I do a gut reset while pregnant or breastfeeding?
Restrictive reset programs are generally not recommended during pregnancy or breastfeeding. However, the foundational habits of eating real food, adding fermented foods, eating a diverse range of plants, drinking bone broth, managing stress, and prioritizing sleep are appropriate and beneficial during these phases. Talk to your healthcare provider about anything more structured.
Where to Start Today
Gut health is not a quick fix and it is not a single supplement. It is a daily practice built on foundational habits: eating real food, diversifying your plants, adding fermented foods, drinking bone broth, sleeping well, managing stress, and moving your body. Most of my patients see meaningful improvement in their gut symptoms within two to four weeks of consistent habits. The gut lining itself replaces its cells about every five to seven days, which is why this works as quickly as it does. Pick one habit to start with this week. A daily cup of Classic Chicken Bone Broth is what I would recommend. Add a fermented food daily next. Then start counting your plant species. If you want a structured starting point, the 5-Day Cleanse and Reset is the fastest way to feel a noticeable shift, and the Bone Broth Diet is the deeper 21-day transformation. Either one gives you a framework. But it is the daily habits, sustained over time, that change the foundation.
References
1. Matar A, Abdelnaem N, Camilleri M. Bone Broth Benefits: How Its Nutrients Fortify Gut Barrier in Health and Disease. Dig Dis Sci. 2025;70(6):1951-1961. Available at: https://pubmed.ncbi.nlm.nih.gov/40180691/
2. Macura B, Kiecka A, Szczepanik M. Intestinal permeability disturbances: causes, diseases and therapy. Clin Exp Med. 2024;24(1):232. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438725/
3. Soh J, Raventhiran S, Lee JH, Lim ZX, Goh J, Kennedy BK, Maier AB. The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review. GeroScience. 2024;46(1):219-239. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828290/
4. Doma KM, Moulin M, Al-Wahsh H, Guthrie N, Crowley DC, Lewis ED. An open-label clinical trial to investigate the safety and efficacy of a bone broth diet on weight loss in adults with obesity. Clin Nutr Open Sci. 2025;61:231-240. (Funded by Veyl Ventures LLC; conducted by KGK Science Inc., an independent clinical research organization; ClinicalTrials.gov NCT05740670.) Available at: https://www.sciencedirect.com/science/article/pii/S2667268525000488
5. Semnani-Azad Z, Khan TA, Chiavaroli L, et al. Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials. BMJ. 2025;389:e082007. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175170/
These statements have not been evaluated by the Food and Drug Administration. Dr. Kellyann products are not intended to diagnose, treat, cure, or prevent any disease. Persistent or significant digestive symptoms should be evaluated by a qualified healthcare provider, as they may indicate a treatable medical condition. Consult your healthcare provider before starting any new dietary program, especially if you are pregnant, nursing, taking medication, or have a medical condition.
